This is an inherited condition where the inner structures of the eyes fail to properly develop, potentially leading ultimately to blindness. Some dogs may be more mildly affected, but could still go on to produce more severely affected offspring.

Goniodysgenesis and Glaucoma Glaucoma can be an extremely painful eye condition in collies, and even result in dogs losing either one or both eyes. At the heart of the problem is some malfunction in the way a fluid, called aqueous humor, drains from the eye. Predisposition to this problem has now been linked to a specific genetic mutation that can be tested for.

TNS is an immune system disease, where the vital white cells needed to fight off infection remain trapped in bone marrow and cannot enter the blood stream. Meaning dogs with this condition rarely live long.

Also known as Storage Disease, this is a metabolic disorder where a specific gene mutation causes an accumulation of more toxic chemicals in the body, damaging nerve cells. Symptoms - like abnormal gait and demented behavior - may not appear until a dog is 18 months old, thereafter dogs rarely live much beyond 2-3 years.

This gene defect makes it easier for more toxic chemicals or medications to leak into the dog's major organs and brain. 

A genetic test for this specific disease, makes EVEN THE CARRIERS are AFFECTED. Due to the fact that it is a deletion in the gene. Meaning that even with one out of two alleles missing, by taking a simple drug such as a deworming pill, can cause a dog to have a seizure and instant death.

This is a genetic disorder where Vitamin B12 (also known as Cobalamin) fails to be absorbed from the intestine. Potentially leading to irreversible damage to the brain and nervous system. Symptoms can include anorexia, lethargy and failure to gain weight.

A severe neurological disease, caused by the progressive deterioration of sensory and nerve cells. Symptoms begin around 2-7 months of age and dogs rarely live beyond 2 years. Most commonly they are euthanized as their life quality is so poor.

Characterized by a more sudden and rapid increase in body temperature, followed by muscle rigidity, a rapid and irregular heartbeat and unstable blood pressure, it can also lead on to kidney failure and death. In susceptible individuals it can be triggered by anything from excitement or exercise to specific drugs or an anesthetic.

Dental Hypomineralisation: The disorder causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Von Willebrand’s disease is the most common inherited bleeding disorder in dogs and occurs when there is a lack of functional von Willebrand factor.  Von Willebrand factor is needed for the normal adhesion of platelets and for normal blood clotting to occur. 

Primary lens luxation (PLL) is thought to be heritable in most breeds in which it is seen, although clinical signs are generally not seen until the dog is an adult. The lens may partially or fully luxate into the front chamber of the eye, causing acute glaucoma (increased pressure within the eye). Sometimes the lens may fall backwards into the posterior (back) chamber of the eye, which may displace the vitreous forwards. This may then also lead to a blockage of drainage of fluid from the eye and a secondary glaucoma.

Neuronal Ceroid Lipofuscinosis 5 (Border collie type), A defect in metabolism leads to a build up of a pigmented toxin called ceroid lipofuscin within cells, including those of the brain and retina. This causes death of brain cells, as they cannot function normally as this waste product continues to build up.

(Cattle Dog Type)Myotonia congenita also known as myotonia hereditaria (Australian cattle dog type) is an inherited muscle disorder affecting dogs. The muscle cells of an affected dog are over-excitable, which causes muscles to remain contracted rather than relaxing after voluntary activity.

Signs are due to the immune-mediated destruction of a part of the nerves in the spinal cord, leading to loss of these nerve fibers. The first sign is knuckling of the hind feet, and hind limb ataxia. Once the spinal cord damage progresses past this initial stage (termed proprioceptive deficits), the effectiveness (if any) of treatment is much diminished.